After finally catching serial killer and occult 'sorcerer' Lord Blackwood, legendary sleuth Sherlock Holmes and his assistant Dr. Watson can close yet another successful case. After his execution, Blackwood mysteriously returns from the grave and resumes his killing spree, Holmes must take up the hunt once again. Contending with Watson's new fiancée and the dimwitted head of Scotland Yard, the determined detective must unravel the clues that will...

Holmes and his assistant Dr. Watson are on the trail of Lord Blackwood, a serial killer they captured and saw executed, but has apparently risen from the grave to resume his killing spree; Sherlock Holmes and Dr. Watson seek out their nemesis Dr. Moriarty, believed to be behind the rising tensions between European countries.