Paul Giamatti stars as himself, agonizing over his interpretation of Anton Chekhov's Classic Play, "Uncle Vanya." Paralyzed by anxiety, he stumbles upon a solution via a New Yorker article about a high-tech company promising to alleviate suffering by extracting souls.. Giamatti enlists their service -- only to discover that his soul is the shape and size of a chickpea. His intention is to reinstate it once he survives the performance but complications...

First-year med student, Joe Slovak, enrolls in Gross Anatomy - the toughest course in school. His free-wheeling life style puts him at odds with his demanding professor and creates problems when he falls in love with his no- nonsense lab partner.