A lethal virus spreads throughout Great Britain, infecting millions and killing hundreds of thousands. To contain the threat the government evacuates as many survivors as it can out of the infected area and the rest of the country succumbs to fear and chaos. The quarantine is successful. Three decades later, the Reaper Virus violently resurfaces. An elite group of specialists, including Eden Sinclair, is urgently dispatched into the still-quarantined...

Reunite with the perplexing and prickly Dr. Gregory House as he tackles impossible cases while putting a new staff of potential team members through the medical wringer with his trademark sarcasm and irreverent bedside manner.